Structure of PDB 4dq1 Chain A

Receptor sequence
>4dq1A (length=312) Species: 158878 (Staphylococcus aureus subsp. aureus Mu50) [Search protein sequence]
NSFDAAYHSLCEEVLEIGNTRNDRTNTGTISKFGHQLRFDLSKGFPLLTT
KKVSFKLVATELLWFIKGDTNIQYLLKYNNNIWNEWAFENYIKSDEYNGP
DMTDFGHRALSDPEFNEQYKEQMKQFKQRILEDDTFAKQFGDLGNVYGKQ
WRDWVDKDGNHFDQLKTVIEQIKHNPDSRRHIVSAWNPTEIDTMALPPCH
TMFQFYVQDGKLSCQLYQRSADIFLGVPFNIASYALLTHLIAKECGLEVG
EFVHTFGDAHIYSNHIDAIQTQLARESFNPPTLKINSDKSIFDINYEDLE
IVDYESHPAIKA
3D structure
PDB4dq1 Thymidylate synthase from Staphylococcus aureus.
ChainA
Resolution2.71 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E63 W85 Y149 C201 R221 D224
Catalytic site (residue number reindexed from 1) E61 W83 Y147 C199 R219 D222
Enzyme Commision number 2.1.1.45: thymidylate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UMP A R26 C201 H202 Q220 R221 S222 A223 D224 N232 H262 Y264 R24 C199 H200 Q218 R219 S220 A221 D222 N230 H260 Y262
BS02 UMP A R181 R182 R179 R180
Gene Ontology
Molecular Function
GO:0004799 thymidylate synthase activity
GO:0008168 methyltransferase activity
GO:0016741 transferase activity, transferring one-carbon groups
Biological Process
GO:0006231 dTMP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0032259 methylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4dq1, PDBe:4dq1, PDBj:4dq1
PDBsum4dq1
PubMed
UniProtP67046|TYSY_STAAM Thymidylate synthase (Gene Name=thyA)

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