Structure of PDB 4dpy Chain A

Receptor sequence
>4dpyA (length=330) Species: 1282 (Staphylococcus epidermidis) [Search protein sequence]
TGSMVKSGKARAHTNIALIKYWGKADETYIIPMNNSLSVTLDRFYTETKV
TFDPDFTEDCLILNGNEVNAKEKEKIQNYMNIVRDLAGNRLHARIESENY
VPTAAGLASSASAYAALAAACNEALSLNLSDTDLSRLARRGSGSASRSIF
GGFAEWEKGHDDLTSYAHGINSNGWEKDLSMIFVVINNQSKKVSARSGMS
LTRDTSRFYQYWLDHVDEDLNEAKEAVKNQDFQRLGEVIEANGLRMHATN
LGAQPPFTYLVQESYDAMAIVEQCRKANLPCYFTMDAGPNVKVLVEKKNK
QAVMEQFLKVFDESKIIASDIISSGVEIIK
3D structure
PDB4dpy Structural basis for nucleotide binding and reaction catalysis in mevalonate diphosphate decarboxylase.
ChainA
Resolution2.14 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 4.1.1.33: diphosphomevalonate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2P0 A A14 K17 Y18 K21 S139 G140 S141 R144 A192 R193 D283 A17 K20 Y21 K24 S142 G143 S144 R147 A195 R196 D286 PDBbind-CN: -logKd/Ki=5.37,Ki=4.3uM
Gene Ontology
Molecular Function
GO:0004163 diphosphomevalonate decarboxylase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016829 lyase activity
GO:0016831 carboxy-lyase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0008299 isoprenoid biosynthetic process
GO:0016310 phosphorylation
GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway
Cellular Component
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4dpy, PDBe:4dpy, PDBj:4dpy
PDBsum4dpy
PubMed22734632
UniProtQ9FD73

[Back to BioLiP]