Structure of PDB 4dpw Chain A

Receptor sequence
>4dpwA (length=326) Species: 1282 (Staphylococcus epidermidis) [Search protein sequence]
MVKSGKARAHTNIALIKYWGKADETYIIPMNNSLSVTLDRFYTETKVTFD
PDFTEDCLILNGNEVNAKEKEKIQNYMNIVRDLAGNRLHARIESENYVPT
AAGLASSASAYAALAAACNEALSLNLSDTDLSRLARRGSGSASRSIFGGF
AEWEKGHDDLTSYAHGINSNGWEKDLSMIFVVINNQSKKVSSRSGMSLTR
DTSRFYQYWLDHVDEDLNEAKEAVKNQDFQRLGEVIEANGLRMHATNLGA
QPPFTYLVQESYDAMAIVEQCRKANLPCYFTMAAGPNVKVLVEKKNKQAV
MEQFLKVFDESKIIASDIISSGVEII
3D structure
PDB4dpw Structural basis for nucleotide binding and reaction catalysis in mevalonate diphosphate decarboxylase.
ChainA
Resolution2.605 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.1.1.33: diphosphomevalonate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AGS A L60 E69 S94 N96 A101 G103 A105 S106 S107 A110 K188 S192 L60 E69 S94 N96 A101 G103 A105 S106 S107 A110 K188 S192
BS02 DP6 A I13 A14 K17 Y18 K21 S107 S139 G140 S141 R193 A283 I13 A14 K17 Y18 K21 S107 S139 G140 S141 R193 A283
Gene Ontology
Molecular Function
GO:0004163 diphosphomevalonate decarboxylase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016829 lyase activity
GO:0016831 carboxy-lyase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0008299 isoprenoid biosynthetic process
GO:0016310 phosphorylation
GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4dpw, PDBe:4dpw, PDBj:4dpw
PDBsum4dpw
PubMed22734632
UniProtQ9FD73

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