Structure of PDB 4dnj Chain A

Receptor sequence
>4dnjA (length=399) Species: 258594 (Rhodopseudomonas palustris CGA009) [Search protein sequence]
SQHGAGVPHLGIDPFALDYFADPYPEQETLREAGPVVYLDKWNVYGVARY
AEVYAVLNDPLTFCSSRGVGLSDFKKEKPWRPPSLILEADPPAHTRTRAV
LSKVLSPATMKRLRDGFAAAADAKIDELLARGGNIDAIADLAEAYPLSVF
PDAMGLKQEGRENLLPYAGLVFNAFGPPNELRQSAIERSAPHQAYVAEQC
QRPNLAPGGFGACIHAFSDTGEITPEEAPLLVRSLLSAGLDTTVNGIAAA
VYCLARFPDEFARLRADPSLARNAFEEAVRFESPVQTFFRTTTRDVELAG
ATIGEGEKVLMFLGSANRDPRRWDDPDRYDITRKTSGHVGFGSGVHMCVG
QLVARLEGEVVLAALARKVAAIEIAGPLKRRFNNTLRGLESLPIQLTPA
3D structure
PDB4dnj The crystal structures of 4-methoxybenzoate bound CYP199A2 and CYP199A4: structural changes on substrate binding and the identification of an anion binding site
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N186 A251 D254 T255 T256 C361 V362 G363 E370 L399
Catalytic site (residue number reindexed from 1) N173 A238 D241 T242 T243 C348 V349 G350 E357 L386
Enzyme Commision number 1.14.99.15: 4-methoxybenzoate monooxygenase (O-demethylating).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM A I99 L100 H107 R111 A251 G252 T255 V298 F301 R303 G353 F354 H359 C361 V362 G363 A367 I86 L87 H94 R98 A238 G239 T242 V285 F288 R290 G340 F341 H346 C348 V349 G350 A354
BS02 ANN A S97 L100 F185 S247 S250 A251 F301 S84 L87 F172 S234 S237 A238 F288
BS03 CL A Y180 Q206 Y167 Q193
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0018690 4-methoxybenzoate monooxygenase (O-demethylating) activity
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0006805 xenobiotic metabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Cellular Component
External links
PDB RCSB:4dnj, PDBe:4dnj, PDBj:4dnj
PDBsum4dnj
PubMed22695988
UniProtQ6N8N2|CYPA2_RHOPA Cytochrome p450 CYP199A2 (Gene Name=cyp199a2)

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