Structure of PDB 4dna Chain A

Receptor sequence
>4dnaA (length=461) Species: 266834 (Sinorhizobium meliloti 1021) [Search protein sequence]
AFDYDLFVIGGGSGGVRSGRLAAALGKKVAIAEEFRYGGTCVIRGCVPKK
LYVYASQFAEHFEDAAGFGWTVGESRFDWAKLVAAKEQEIARLEGLYRKG
LANAGAEILDTRAELAGPNTVKLLASGKTVTAERIVIAVGGHPSPHDALP
GHELCITSNEAFDLPALPESILIAGGGYIAVEFANIFHGLGVKTTLIYRG
KEILSRFDQDMRRGLHAAMEEKGIRILCEDIIQSVSADADGRRVATTMKH
GEIVADQVMLALGRMPNTNGLGLEAAGVRTNELGAIIVDAFSRTSTPGIY
ALGDVTDRVQLTPVAIHEAMCFIETEYKNNPTSPDHDLIATAVFSQPEIG
TVGITEEEAARKFQEIEVYRAEFRPMKATLSGRKEKTIMKLVVNAADRKV
VGAHILGHDAGEMAQLLGISLRAGCTKDDFDRTMAVHPTAAEELVTMYQP
SYRVRNGERVG
3D structure
PDB4dna CRYSTAL STRUCTURE OF putative glutathione reductase from Sinorhizobium meliloti 1021
ChainA
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y39 C43 C48 K51 Y180 E184 A437 H439 E444 G463
Catalytic site (residue number reindexed from 1) Y37 C41 C46 K49 Y178 E182 A435 H437 E442 G461
Enzyme Commision number 1.8.1.7: glutathione-disulfide reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A I11 G12 G13 G14 G16 E35 E36 G41 T42 C43 G47 C48 K51 R114 A115 V141 G142 Y180 R266 G305 D306 Q312 L313 T314 I9 G10 G11 G12 G14 E33 E34 G39 T40 C41 G45 C46 K49 R112 A113 V139 G140 Y178 R264 G303 D304 Q310 L311 T312
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004362 glutathione-disulfide reductase (NADPH) activity
GO:0016491 oxidoreductase activity
GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
Biological Process
GO:0006749 glutathione metabolic process
GO:0034599 cellular response to oxidative stress
GO:0045454 cell redox homeostasis
GO:0098869 cellular oxidant detoxification
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:4dna, PDBe:4dna, PDBj:4dna
PDBsum4dna
PubMed
UniProtQ92PC0

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