Structure of PDB 4dmw Chain A

Receptor sequence
>4dmwA (length=535) Species: 1496 (Clostridioides difficile) [Search protein sequence]
SLISKEELIKLAYSIRPRENEYKTILTNLDEYNKLTTNNNENKYLQLKKL
NESIDVFMNKYKTSSRNRALSNLKKDILKEVILIKNSNTSPVEKNLHFVW
IGGEVSDIALEYIKQWADINAEYNIKLWYDSEAFLVNTLKKAIVESSTTE
ALQLLEEEIQNPQFDNMKFYKKRMEFIYDRQKRFINYYKSQINKVPTIDD
IIKSHLVSEYNRDETVLESYRTNSLRKINSNHGIDIRANSLFTEQELLNI
YSQELLNRGNLAAASDIVRLLALKNFGGVYLDVDMLPGIHSDLFKTISRP
SSIGLDRWEMIKLEAIMKYKKYINNYTSENFDKLDQQLKDNFKLIIESKS
EKSEIFSKLENLNVSDLEIKIAFALGSVINQALISKQGSYLTNLVIEQVK
NRYQFLNQHLNPAIESDNNFTDTTKIFHDSLFNSATAENSMFLTKIAPYL
QVGFMPEARSTISLSGPGAYASAYYDFINLQENTIEKTLKASDLIEFKFP
ENNLSQLTEQEINSLWSFDQASAKYQFEKYVRDYT
3D structure
PDB4dmw The structure of Clostridium difficile toxin A glucosyltransferase domain bound to Mn2+ and UDP provides insights into glucosyltransferase activity and product release.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.-
3.4.22.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A D287 E514 D284 E511
BS02 UDP A V100 W101 I102 L264 S268 D285 S517 V99 W100 I101 L261 S265 D282 S514 PDBbind-CN: -logKd/Ki=4.94,Kd=11.4uM
Gene Ontology
Molecular Function
GO:0016757 glycosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:4dmw, PDBe:4dmw, PDBj:4dmw
PDBsum4dmw
PubMed22747490
UniProtP16154|TCDA_CLODI Toxin A (Gene Name=tcdA)

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