Structure of PDB 4dm8 Chain A

Receptor sequence
>4dm8A (length=238) Species: 9606 (Homo sapiens) [Search protein sequence]
ESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLW
DKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICT
RYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTE
TGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPPHMFPKI
LMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLE
3D structure
PDB4dm8 Structural basis for a molecular allosteric control mechanism of cofactor binding to nuclear receptors.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K246 I260 L411 E414 K69 I83 L232 E235
BS02 REA A F230 L233 A234 L271 I272 F288 S289 L400 F53 L56 A57 L94 I95 F111 S112 L221
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0048384 retinoic acid receptor signaling pathway
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4dm8, PDBe:4dm8, PDBj:4dm8
PDBsum4dm8
PubMed22355136
UniProtP10826|RARB_HUMAN Retinoic acid receptor beta (Gene Name=RARB)

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