Structure of PDB 4dlx Chain A

Receptor sequence
>4dlxA (length=166) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGET
CLLDILDTAGQEEYSAMRDEYMRTGEGFLCVFAINNTKSFEDIHQYREQI
KRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQ
GVEDAFYTLVREIRQH
3D structure
PDB4dlx Shift in the Equilibrium between On and Off States of the Allosteric Switch in Ras-GppNHp Affected by Small Molecules and Bulk Solvent Composition.
ChainA
Resolution1.731 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A F28 D30 F28 D30
BS02 MG A S17 T35 S17 T35
BS03 MG A R102 D105 R102 D105
BS04 GNP A G13 G15 K16 S17 A18 F28 V29 D30 E31 Y32 P34 T35 G60 N116 K117 D119 L120 S145 A146 G13 G15 K16 S17 A18 F28 V29 D30 E31 Y32 P34 T35 G60 N116 K117 D119 L120 S145 A146
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:4dlx, PDBe:4dlx, PDBj:4dlx
PDBsum4dlx
PubMed22845804
UniProtP01112|RASH_HUMAN GTPase HRas (Gene Name=HRAS)

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