Structure of PDB 4dl9 Chain A

Receptor sequence

>4dl9A (length=379) Species: 4081 (Solanum lycopersicum)

SATQGQVITCKAAVAWEPNKPLVIEDVQVAPPQAGEVRVKVLYTALCHTD
AYTWSGKDPEGLFPCVLGHEAAGIVESVGEGVTEVQPGDHVIPCYQAECR
ECKFCKSGKTNLCGKVRAATGVGVMMNDRKSRFSINGKPIYHFMGTSTFS
QYTVVHDVSVAKIDPVAPLEKVCLLGCGVPTGLGAVWNTAKVEPGSIVAV
FGLGTVGLAVAEGAKAAGASRIIGIDIDSKKFDRAKNFGVTEFINPKEHE
QPIQQVIVDLTDGGVDYSFECIGNVSVMRSALECCHKGWGTSVIVGVAAS
GQEISTRPFQLVTGRVWKGTAFGGFKSRSQVPSLVDKYLKKEIKVDEYIT
HNMTLADINKAFDLMHDGDCLRVVLDMFV

3D structure

• PDB: 4dl9 Structural and functional characterization of a plant S-nitrosoglutathione reductase from Solanum lycopersicum.
• Chain: A
• Resolution: 1.85 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): C47 H48 T49 Y52 H69 E70 C99 C102 C105 C113 R117 C177 T181 R372
• Catalytic site (residue number reindexed from 1): C47 H48 T49 Y52 H69 E70 C99 C102 C105 C113 R117 C177 T181 R372
• Enzyme Commision number: 1.1.1.284: S-(hydroxymethyl)glutathione dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	C47 H69 E70 C177	C47 H69 E70 C177
BS02	ZN	A	C99 C102 C105 C113	C99 C102 C105 C113
BS03	NAD	A	Y95 T181 G204 V206 D226 I227 K231 C271 I272 V295 G296 V297 A321 F322	Y95 T181 G204 V206 D226 I227 K231 C271 I272 V295 G296 V297 A321 F322

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0004022 alcohol dehydrogenase (NAD+) activity
• GO:0008270 zinc ion binding
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding
• GO:0051903 S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity

Biological Process

• GO:0044281 small molecule metabolic process
• GO:0046294 formaldehyde catabolic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:4dl9, PDBe:4dl9, PDBj:4dl9
• PDBsum: 4dl9
• PubMed: 23274177
• UniProt: D2Y3F4