Structure of PDB 4dl8 Chain A

Receptor sequence
>4dl8A (length=224) Species: 5691 (Trypanosoma brucei) [Search protein sequence]
VSLSPLILRSLAELQDGLNTVVDKNWRQLRRPGDWSLAITMEAAELLDSY
PWKWWKNVKAQPDLQNVKIELTDILHFSLSGAMQVSDENLADFMFFPLSD
TNNALASFQNIIRLASLQRFQLVTSAVIAAADDIGFNLVAYYVAKHTLNG
IRQMKGYKDGTYVKVQKGVEDNELLHGCISPFSLDDVTNEGNYKTKWDDI
MHRVYDAFGTPKEERLNIGHWLKS
3D structure
PDB4dl8 On the catalytic mechanism of dimeric dUTPases.
ChainA
Resolution1.698 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.23: dUTP diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UMP A Q21 N25 D79 H82 F83 N212 R215 Y220 Q15 N19 D73 H76 F77 N149 R152 Y157
BS02 AF3 A E48 E51 D79 K208 R215 K227 E42 E45 D73 K145 R152 K164
BS03 PO4 A E51 K227 E45 K164
BS04 MG A E48 E51 E42 E45
BS05 MG A E48 E51 E76 D79 E42 E45 E70 D73
Gene Ontology
Molecular Function
GO:0004170 dUTP diphosphatase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Cellular Component
GO:0005654 nucleoplasm
GO:0005829 cytosol

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Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:4dl8, PDBe:4dl8, PDBj:4dl8
PDBsum4dl8
PubMed24001052
UniProtQ57ZH3

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