Structure of PDB 4dl7 Chain A

Receptor sequence

>4dl7A (length=426) Species: 9606 (Homo sapiens)

GPHMATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGI
IAVSYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASV
EVMEIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYI
EGLPQGTVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAA
IERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIR
KIRSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCR
GIEHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLT
KDRNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVI
KNCNTSTEWSPPLTMLFLCATKFSAS

3D structure

• PDB: 4dl7 Structural Basis for Chemoresistance to Cisplatin Mediated by DNA Polymerase eta
• Chain: A
• Resolution: 1.97 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.7: DNA-directed DNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	Q38 Y39 W42 S62 K86 R93 K293 P316 K317 T318 G320 C321 S322 K323 N324 P326 G327 R351	Q41 Y42 W45 S65 K89 R96 K290 P313 K314 T315 G317 C318 S319 K320 N321 P323 G324 R348
BS02	dna	A	R61 K224 S257 G259 G260 K261 L262 R382	R64 K221 S254 G256 G257 K258 L259 R379
BS03	DZ4	A	S257 K293 N294 W297	S254 K290 N291 W294

Gene Ontology

Molecular Function

• GO:0003684 damaged DNA binding

Biological Process

• GO:0006281 DNA repair

External links

• PDB: RCSB:4dl7, PDBe:4dl7, PDBj:4dl7
• PDBsum: 4dl7
• PubMed: 22529383
• UniProt: Q9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)