Structure of PDB 4dl6 Chain A

Receptor sequence

>4dl6A (length=424) Species: 9606 (Homo sapiens)

TGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVSY
EARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVMEI
MSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGLPQ
GPEETVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIE
RETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKI
RSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGI
EHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKD
RNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKN
CNTSTEWSPPLTMLFLCATKFSAS

3D structure

• PDB: 4dl6 Structural Basis for Chemoresistance to Cisplatin Mediated by DNA Polymerase eta
• Chain: A
• Resolution: 2.5 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.7: DNA-directed DNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	Q38 Y39 W42 S62 W64 K86 R93 P316 K317 T318 G320 C321 S322 K323 N324 R351	Q36 Y37 W40 S60 W62 K84 R91 P311 K312 T313 G315 C316 S317 K318 N319 R346
BS02	dna	A	S113 S257 G259 K261 L262 R377 R382 C384	S111 S252 G254 K256 L257 R372 R377 C379
BS03	MG	A	D13 M14 D115	D11 M12 D113
BS04	MG	A	D13 D115 E116	D11 D113 E114
BS05	XG4	A	D13 M14 D15 C16 F17 F18 I48 Y52 R55 D115 K231	D11 M12 D13 C14 F15 F16 I46 Y50 R53 D113 K226

Gene Ontology

Molecular Function

• GO:0003684 damaged DNA binding

Biological Process

• GO:0006281 DNA repair

External links

• PDB: RCSB:4dl6, PDBe:4dl6, PDBj:4dl6
• PDBsum: 4dl6
• PubMed: 22529383
• UniProt: Q9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)