Structure of PDB 4dl5 Chain A

Receptor sequence

>4dl5A (length=424) Species: 9606 (Homo sapiens)

ATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVS
YEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVME
IMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGLP
QGEETVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIE
RETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKI
RSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGI
EHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKD
RNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKN
CNTSTEWSPPLTMLFLCATKFSAS

3D structure

• PDB: 4dl5 Structural Basis for Chemoresistance to Cisplatin Mediated by DNA Polymerase eta
• Chain: A
• Resolution: 2.92 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.7: DNA-directed DNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	Q38 Y39 K86 R93 K293 R313 K317 T318 G320 S322 K323 N324 R351	Q37 Y38 K85 R92 K288 R308 K312 T313 G315 S317 K318 N319 R346
BS02	dna	A	S113 E116 S257 G259 K261 L262 R382	S112 E115 S252 G254 K256 L257 R377
BS03	MG	A	D13 M14 D115	D12 M13 D114
BS04	MG	A	D13 D115 E116	D12 D114 E115
BS05	0KX	A	D13 M14 D15 C16 F17 F18 Y52 R55 R61 D115 K231	D12 M13 D14 C15 F16 F17 Y51 R54 R60 D114 K226

Gene Ontology

Molecular Function

• GO:0003684 damaged DNA binding

Biological Process

• GO:0006281 DNA repair

External links

• PDB: RCSB:4dl5, PDBe:4dl5, PDBj:4dl5
• PDBsum: 4dl5
• PubMed: 22529383
• UniProt: Q9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)