Structure of PDB 4dl4 Chain A

Receptor sequence

>4dl4A (length=429) Species: 9606 (Homo sapiens)

MATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAV
SYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVM
EIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGL
PQGPEETVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAA
IERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIR
KIRSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCR
GIEHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLT
KDRNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVI
KNCNTSGIQTEWSPPLTMLFLCATKFSAS

3D structure

• PDB: 4dl4 Structural Basis for Chemoresistance to Cisplatin Mediated by DNA Polymerase eta
• Chain: A
• Resolution: 2.0 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.7: DNA-directed DNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	Q38 Y39 G46 I47 R61 S62 W64 K86 R93 K311 P316 K317 T318 G320 C321 S322 K323 N324 P326 R351	Q38 Y39 G46 I47 R61 S62 W64 K86 R93 K308 P313 K314 T315 G317 C318 S319 K320 N321 P323 R348
BS02	dna	A	S113 E116 K224 S257 G259 G260 K261 L262 R377 R382	S113 E116 K221 S254 G256 G257 K258 L259 R374 R379
BS03	MG	A	D13 D115 E116	D13 D115 E116
BS04	MG	A	D13 M14 D115	D13 M14 D115
BS05	0KX	A	D13 M14 D15 C16 F17 F18 Y52 R55 R61 D115 K231	D13 M14 D15 C16 F17 F18 Y52 R55 R61 D115 K228

Gene Ontology

Molecular Function

• GO:0003684 damaged DNA binding

Biological Process

• GO:0006281 DNA repair

External links

• PDB: RCSB:4dl4, PDBe:4dl4, PDBj:4dl4
• PDBsum: 4dl4
• PubMed: 22529383
• UniProt: Q9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)