Structure of PDB 4dl2 Chain A

Receptor sequence

>4dl2A (length=428) Species: 9606 (Homo sapiens)

ATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVS
YEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVME
IMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGLP
QGPEETVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAI
ERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRK
IRSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRG
IEHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTK
DRNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIK
NCNTSGIQTEWSPPLTMLFLCATKFSAS

3D structure

• PDB: 4dl2 Structural Basis for Chemoresistance to Cisplatin Mediated by DNA Polymerase eta
• Chain: A
• Resolution: 2.15 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.7: DNA-directed DNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	Q38 Y39 W42 I48 S62 K86 R93 P316 K317 T318 G320 C321 S322 K323 N324 P326 R351	Q37 Y38 W41 I47 S61 K85 R92 P312 K313 T314 G316 C317 S318 K319 N320 P322 R347
BS02	dna	A	S113 E116 K224 S257 G259 G260 K261 L262 R377 R382 C384	S112 E115 K220 S253 G255 G256 K257 L258 R373 R378 C380
BS03	MG	A	D13 M14 D115	D12 M13 D114
BS04	MG	A	D13 D115 E116	D12 D114 E115
BS05	0KX	A	D13 D15 C16 F17 F18 Y52 R55 R61 D115 K231	D12 D14 C15 F16 F17 Y51 R54 R60 D114 K227

Gene Ontology

Molecular Function

• GO:0003684 damaged DNA binding

Biological Process

• GO:0006281 DNA repair

External links

• PDB: RCSB:4dl2, PDBe:4dl2, PDBj:4dl2
• PDBsum: 4dl2
• PubMed: 22529383
• UniProt: Q9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)