Structure of PDB 4dkp Chain A

Receptor sequence
>4dkpA (length=339) Species: 11686 (Human immunodeficiency virus type 1 (BRU ISOLATE)) [Search protein sequence]
VWKDADTTLFCASDAKAHETEVHNVWATHACVPTDPNPQEIHLENVTENF
NMWKNNMVEQMQEDVISLWDQSLQPCVKLTGGSVIKQACPKISFDPIPIH
YCTPAGYVILKCNDKNFNGTGPCKNVSSVQCTHGIKPVVSTQLLLNGSLA
EEEIIIRSENLTNNAKTIIVHLNKSVEINCTRPSNGDIRKAYCEINGTKW
NKVLKQVTEKLKEHFNNKTIIFQPPSGGDLEITMHSFNCRGEFFYCNTTQ
LFNNTCINGTITLPCKIKQIINMWQGTGQAMYAPPIDGKINCVSNITGIL
LTRDGGANNTSNETFRPGGGNIKDNWRSELYKYKVVQIE
3D structure
PDB4dkp Structure-Based Design, Synthesis, and Characterization of Dual Hotspot Small-Molecule HIV-1 Entry Inhibitors.
ChainA
Resolution1.7978 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0LL A S256 T257 E370 S375 F376 F382 I424 N425 W427 S140 T141 E231 S236 F237 F243 I271 N272 W274 MOAD: Kd=1.9uM
PDBbind-CN: -logKd/Ki=5.72,Kd=1.9uM
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:4dkp, PDBe:4dkp, PDBj:4dkp
PDBsum4dkp
PubMed22497421
UniProtQ0ED31

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