Structure of PDB 4dk8 Chain A

Receptor sequence
>4dk8A (length=233) Species: 9606 (Homo sapiens) [Search protein sequence]
MQLTAAQELMIQQLVAAQLQCNKRSFSKVTPWPQSRDARQQRFAHFTELA
IISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETE
CITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIA
INIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKL
VSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWD
3D structure
PDB4dk8 Discovery of a new binding mode for a series of liver X receptor agonists.
ChainA
Resolution2.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A D284 K287 R297 E298 I301 K305 E455 D59 K62 R72 E73 I76 K80 E230
BS02 0KT A F271 M312 T316 F329 H435 W457 F46 M87 T91 F104 H210 W232 PDBbind-CN: -logKd/Ki=5.74,IC50=1.8uM
BS03 CA A Q235 E281 E315 Q18 E56 E90
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006629 lipid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4dk8, PDBe:4dk8, PDBj:4dk8
PDBsum4dk8
PubMed22406115
UniProtP55055|NR1H2_HUMAN Oxysterols receptor LXR-beta (Gene Name=NR1H2)

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