Structure of PDB 4dk7 Chain A

Receptor sequence
>4dk7A (length=235) Species: 9606 (Homo sapiens) [Search protein sequence]
HMQLTAAQELMIQQLVAAQLQCNKRSFSKVTPWPLSRDARQQRFAHFTEL
AIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHET
ECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLI
AINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMK
LVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDV
3D structure
PDB4dk7 Discovery of a new binding mode for a series of liver X receptor agonists.
ChainA
Resolution2.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K287 R297 E298 I301 K305 P451 L452 E455 K63 R73 E74 I77 K81 P227 L228 E231
BS02 0KS A L274 A275 S278 T316 F329 F340 H435 L449 W457 L50 A51 S54 T92 F105 F116 H211 L225 W233 MOAD: ic50=0.02uM
PDBbind-CN: -logKd/Ki=7.70,IC50=0.02uM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006629 lipid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4dk7, PDBe:4dk7, PDBj:4dk7
PDBsum4dk7
PubMed22406115
UniProtP55055|NR1H2_HUMAN Oxysterols receptor LXR-beta (Gene Name=NR1H2)

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