Structure of PDB 4dk4 Chain A

Receptor sequence
>4dk4A (length=218) Species: 5691 (Trypanosoma brucei) [Search protein sequence]
SLSPLILRSLAELQDGLNTVVDKNWRQLRRPGDWSLAITMEAAELLDSYP
WKWWKNVKAQPDLQNVKIELTDILHFSLSGAMQVSADFMFFPLSDTNNAL
ASFQNIIRLASLQRFQLVTSAVIAAADDIGFNLVAYYVAKHTLNGIRQMK
GYKDGTYVKVQKGVEDNELLHGCISPFSLDDVTNEGNYKTKWDDIMHRVY
DAFGTPKEERLNIGHWLK
3D structure
PDB4dk4 On the catalytic mechanism of dimeric dUTPases.
ChainA
Resolution1.9 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.6.1.23: dUTP diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DUN A N25 E48 D79 H82 F83 K208 N212 R215 Y220 K227 N18 E41 D72 H75 F76 K140 N144 R147 Y152 K159
BS02 CA A E48 E51 E41 E44
BS03 CA A E48 E51 E76 D79 E41 E44 E69 D72
BS04 DUN A K59 W60 W61 K52 W53 W54
Gene Ontology
Molecular Function
GO:0004170 dUTP diphosphatase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Cellular Component
GO:0005654 nucleoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:4dk4, PDBe:4dk4, PDBj:4dk4
PDBsum4dk4
PubMed24001052
UniProtQ57ZH3

[Back to BioLiP]