Structure of PDB 4dg4 Chain A

Receptor sequence
>4dg4A (length=224) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGYTCEENSLPYQVSLNSGYHFCGGSLISEQWVVSAAHCYKTRIQVRL
GEHNIKVLEGNEQFINAAKIIRHPKYNRDTLDNDIMLIKLSSPAVINARV
STISLPTAPPAAGTECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKA
SYPGKITNSMFCVGFLEGGKDSCQRDAGGPVVCNGQLQGVVSWGHGCAWK
NRPGVYTKVYNYVDWIKDTIAANS
3D structure
PDB4dg4 Presence versus absence of hydrogen bond donor Tyr-39 influences interactions of cationic trypsin and mesotrypsin with protein protease inhibitors.
ChainA
Resolution1.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 Q192 R193 D194 A195 G196
Catalytic site (residue number reindexed from 1) H40 D84 Q174 R175 D176 A177 G178
Enzyme Commision number 3.4.21.4: trypsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A E70 H71 N72 E80 E52 H53 N54 E62
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4dg4, PDBe:4dg4, PDBj:4dg4
PDBsum4dg4
PubMed22610453
UniProtP35030|TRY3_HUMAN Trypsin-3 (Gene Name=PRSS3)

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