Structure of PDB 4del Chain A

Receptor sequence
>4delA (length=345) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
PIATPEVYAEMLGQAKQNSYAFPAINCTSSETVNAAIKGFADAGSDGIIQ
FSTGGAEFGSGLGVKDMVTGAVALAEFTHVIAAKYPVNVALHTDHCPKDK
LDSYVRPLLAISAQRVSKGGNPLFQSHMWDGSAVPIDENLAIAQELLKAA
AAAKIILEIEIGVVGGEEDGVANEINEKLYTSPEDFEKTIEALGAGEHGK
YLLAATFGNVHGVYKPGNVKLRPDILAQGQQVAAAKLGLPADAKPFDFVF
HGGSGSLKSEIEEALRYGVVKMNVDTDTQYAFTRPIAGHMFTNYDGVLKV
DGEVGVKKVYDPRSYLKKAEASMSQRVVQACNDLHCAGKSLTHHH
3D structure
PDB4del Active site loop dynamics of a class IIa fructose 1,6-bisphosphate aldolase from Mycobacterium tuberculosis.
ChainA
Resolution1.58 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D95 H96 E169 H212 H252 N274
Catalytic site (residue number reindexed from 1) D94 H95 E168 H211 H251 N273
Enzyme Commision number 4.1.2.13: fructose-bisphosphate aldolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H96 H212 H252 H95 H211 H251
BS02 ZN A H344 H346 H343 H345
BS03 PGH A D95 H96 H212 G213 H252 G253 S255 N274 D276 T277 D94 H95 H211 G212 H251 G252 S254 N273 D275 T276 MOAD: Kd=21.1nM
PDBbind-CN: -logKd/Ki=7.68,Kd=21.1nM
Gene Ontology
Molecular Function
GO:0004332 fructose-bisphosphate aldolase activity
GO:0008270 zinc ion binding
GO:0016829 lyase activity
GO:0016832 aldehyde-lyase activity
GO:0035375 zymogen binding
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006096 glycolytic process
Cellular Component
GO:0005576 extracellular region
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4del, PDBe:4del, PDBj:4del
PDBsum4del
PubMed23298222
UniProtP9WQA3|ALF_MYCTU Fructose-bisphosphate aldolase (Gene Name=fba)

[Back to BioLiP]