Structure of PDB 4dd8 Chain A

Receptor sequence
>4dd8A (length=201) Species: 9606 (Homo sapiens) [Search protein sequence]
RETRYVELYVVVDNAEFQMLGSEAAVRHRVLEVVNHVDKLYQKLNFRVVL
VGLEIWNSQDRFHVSPDPSVTLENLLTWQARRHLHDNVQLITGVDFTGTT
VGFARVSAMCSHSSGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQG
CRCQERFEAGRCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCLANAP
D
3D structure
PDB4dd8 Structure of human ADAM-8 catalytic domain complexed with batimastat.
ChainA
Resolution2.1 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.4.24.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BAT A T299 T300 V301 G302 F303 H334 E335 H338 H344 G366 S367 T99 T100 V101 G102 F103 H134 E135 H138 H144 G166 S167
BS02 CA A E203 D286 C395 N398 E7 D86 C195 N198
BS03 ZN A H334 H338 H344 H134 H138 H144
BS04 BAT A Q255 R257 Q59 R61
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4dd8, PDBe:4dd8, PDBj:4dd8
PDBsum4dd8
PubMed22684055
UniProtP78325|ADAM8_HUMAN Disintegrin and metalloproteinase domain-containing protein 8 (Gene Name=ADAM8)

[Back to BioLiP]