Structure of PDB 4dce Chain A

Receptor sequence
>4dceA (length=288) Species: 9606 (Homo sapiens) [Search protein sequence]
NPNYSFAGKTSSISDLKEVPRKNITLIRGLGHGEVYEGQVSPSPLQVAVK
TLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMA
GGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDI
AARNCLLTCPGPGRVAKIGDFGGCAMLPVKWMPPEAFMEGIFTSKTDTWS
FGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQ
CWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYG
3D structure
PDB4dce Rapid development of piperidine carboxamides as potent and selective anaplastic lymphoma kinase inhibitors.
ChainA
Resolution2.03 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1249 A1251 R1253 N1254 D1270
Catalytic site (residue number reindexed from 1) D149 A151 R153 N154 D170
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0JF A A1148 K1150 I1171 F1174 V1180 L1196 M1199 G1202 L1256 G1269 D1270 F1271 A48 K50 I71 F74 V80 L96 M99 G102 L156 G169 D170 F171 MOAD: ic50=0.174uM
PDBbind-CN: -logKd/Ki=6.76,IC50=0.174uM
BindingDB: IC50=384nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4dce, PDBe:4dce, PDBj:4dce
PDBsum4dce
PubMed22263917
UniProtQ9UM73|ALK_HUMAN ALK tyrosine kinase receptor (Gene Name=ALK)

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