Structure of PDB 4dcd Chain A

Receptor sequence
>4dcdA (length=184) Species: 12081 (Human poliovirus 1 Mahoney) [Search protein sequence]
HHHHGPGFDYAVAMAKRNIVTATTSKGEFTMLGVHDNVAILPTHASPGES
IVIDGKEVEILDAKALEDQAGTNLEITIITLKRNEKFRDIRPHIPTQITE
TNDGVLIVNTSKYPNMYVPVGAVTEQGYLNLGGRQTARTLMYNFPTRAGQ
CGGVITCTGKVIGMHVGGNGSHGFAAALKRSYFT
3D structure
PDB4dcd Broad-Spectrum Antivirals against 3C or 3C-Like Proteases of Picornaviruses, Noroviruses, and Coronaviruses.
ChainA
Resolution1.69 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H40 E71 G145 C147
Catalytic site (residue number reindexed from 1) H44 E75 G149 C151
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.4.22.29: picornain 2A.
3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 K36 A H40 L127 G128 T142 R143 C147 H161 V162 G163 G164 N165 H44 L131 G132 T146 R147 C151 H165 V166 G167 G168 N169 PDBbind-CN: -logKd/Ki=5.75,IC50=1.77uM
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4dcd, PDBe:4dcd, PDBj:4dcd
PDBsum4dcd
PubMed22915796
UniProtP03300|POLG_POL1M Genome polyprotein

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