Structure of PDB 4dcb Chain A

Receptor sequence
>4dcbA (length=277) Species: 632 (Yersinia pestis) [Search protein sequence]
LIPNISPDSFTVAASTGMLSGKSHEMLYDAETGRKISQLDWKIKNVAILK
GDISWDPYSFLTLNARGWTSLASGSGNMDNYDWMNENQSEWTDHSSHPAT
NVNHANEYDLNVKGWLLQDENYKAGITAGYQETRFSWTATGGSYSYNNGA
YTGNFPKGVRVIGYNQRFSMPYIGLAGQYRINDFELNALFKFSDWVRAHD
NDEHYMRDLTFREKTSGSRYYGTVINAGYYVTPNAKVFAEFTYSKYDEGK
GGTQTIDAAGISNKNYTVTAGLQYRFG
3D structure
PDB4dcb Structural basis for activation of an integral membrane protease by lipopolysaccharide.
ChainA
Resolution2.033 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N84 D86 S99 D206 H208
Catalytic site (residue number reindexed from 1) N80 D82 S95 D202 H204
Enzyme Commision number 3.4.23.48: plasminogen activator Pla.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A N84 D86 M88 D97 Y150 V165 H208 R211 N80 D82 M84 D93 Y146 V161 H204 R207
BS02 C8E A L67 N68 V116 Y134 L63 N64 V112 Y130
Gene Ontology
Molecular Function
GO:0004175 endopeptidase activity
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0009279 cell outer membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4dcb, PDBe:4dcb, PDBj:4dcb
PDBsum4dcb
PubMed22645135
UniProtP17811|PLA_YERPE Plasminogen activator (Gene Name=pla)

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