Structure of PDB 4dc1 Chain A

Receptor sequence
>4dc1A (length=258) Species: 1902 (Streptomyces coelicolor) [Search protein sequence]
QDSEVALVTGATSGIGLEIARRLGKEGLRVFVCARGEEGLRTTLKELREA
GVEADGRTCDVRSVPEIEALVAAVVERYGPVDVLVNNAGRPGGGATAELA
DELWLDVVETNLTGVFRVTKQVLKAGGMLERGTGRIVNIASTGGKQGVVH
AAPYSASKHGVVGFTKALGLELARTGITVNAVCPGFVETPMAASVREHFS
DIWEVSTEEAFDRITARVPIGRYVQPSEVAEMVAYLIGPGAAAVTAQALN
VCGGLGNY
3D structure
PDB4dc1 The Determinants of Activity and Specificity in Actinorhodin Type II Polyketide Ketoreductase.
ChainA
Resolution2.82 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G17 N114 S144 Y157 K161 F202
Catalytic site (residue number reindexed from 1) G14 N111 S141 Y154 K158 F199
Enzyme Commision number 1.3.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NDP A G13 T15 S16 I18 R38 G39 D63 V64 N90 S144 Y157 K161 P187 G188 V190 T192 P193 M194 G10 T12 S13 I15 R35 G36 D60 V61 N87 S141 Y154 K158 P184 G185 V187 T189 P190 M191
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
Biological Process
GO:0008202 steroid metabolic process
GO:0017000 antibiotic biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4dc1, PDBe:4dc1, PDBj:4dc1
PDBsum4dc1
PubMed24035284
UniProtP16544|ACT3_STRCO Putative ketoacyl reductase (Gene Name=actIII)

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