Structure of PDB 4dbz Chain A

Receptor sequence
>4dbzA (length=257) Species: 1902 (Streptomyces coelicolor) [Search protein sequence]
DSEVALVTGATSGIGLEIARRLGKEGLRVFVCARGEEGLRTTLKELREAG
VEADGRTCDVRSVPEIEALVAAVVERYGPVDVLVNNAGRPGGGATAELAD
ELWLDVVETNLTGVFRVTKQVLKAGGMLERGTGRIVNIASTGGKQGLVHA
APYSASKHGVVGFTKALGLELARTGITVNAVCPGFVETPMAASVREHYSD
IWEVSTEEAFDRITARVPIGRYVQPSEVAEMVAYLIGPGAAAVTAQALNV
CGGLGNY
3D structure
PDB4dbz The Determinants of Activity and Specificity in Actinorhodin Type II Polyketide Ketoreductase.
ChainA
Resolution2.643 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G17 N114 S144 Y157 K161 Y202
Catalytic site (residue number reindexed from 1) G13 N110 S140 Y153 K157 Y198
Enzyme Commision number 1.3.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NDP A G13 T15 S16 G17 I18 R38 G39 D63 V64 N90 A91 G92 S144 Y157 K161 V190 T192 P193 M194 G9 T11 S12 G13 I14 R34 G35 D59 V60 N86 A87 G88 S140 Y153 K157 V186 T188 P189 M190
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
Biological Process
GO:0008202 steroid metabolic process
GO:0017000 antibiotic biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4dbz, PDBe:4dbz, PDBj:4dbz
PDBsum4dbz
PubMed24035284
UniProtP16544|ACT3_STRCO Putative ketoacyl reductase (Gene Name=actIII)

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