Structure of PDB 4dbr Chain A

Receptor sequence
>4dbrA (length=754) Species: 9823 (Sus scrofa) [Search protein sequence]
AKPVWAPHPTDGFQVGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEE
DSKKDVEDNCSLMYLNEATLLHNIKVRYSKDRIYTYVANILIAVNPYFDI
PKIYSSETIKSYQGKSLGTMPPHVFAIADKAFRDMKVLKLSQSIIVSGES
GAGKTENTKFVLRYLTESYGTGQDIYDRIVEANPLLEAFGNAKTVRNNNS
SRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGKEERNYHIFYRLCA
GASEDIRERLHLSSPDNFRYLNRGCTRYFANKETDKQILQNRKSPEYLKA
GSLKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFE
EAGGCNLKNKSTQALEYCAELLGLDQDDLRVSLTTRVIKVPLKVEQANNA
RDALAKTVYSHLFDHVVNRVNQCFPFETSSYFIGVLDIAGFEYFEHNSFE
QFCINYCNEKLQQFFNERILKEEQELYQKEGLGVNEVHYVDNQDCIDLIE
ARLVGILDILDEENRLPQPSDQHFTSAVHQKHKDHFRLSIPRKSKLAIHR
NIRDDEGFIIRHFAGAVCYETTQFVEKNNDALHMSLESLICESRDKFIRE
LFESFISVGNKFKTQLNLLLDKLRSTGASFIRCIKPNLKMTSHHFEGAQI
LSQLQCSGMVSVLDLMQGGFPSRASFHELYNMYKKYMPDKLARLDPRLFC
KALFKALGLNEIDYKFGLTKVFFRPGKFAEFDQIMKSDPDHLAELVKRVN
HWLI
3D structure
PDB4dbr Mutations in myosin VI that cause a loss of coordination between heads provide insights into the structural changes underlying force generation and the importance of gating
ChainA
Resolution1.95 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S153 G154 T158 N200 S203 S204 G459 E461
Catalytic site (residue number reindexed from 1) S150 G151 T155 N197 S200 S201 G440 E442
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A N98 P99 Y100 F101 G154 G156 K157 T158 E159 F163 N200 N95 P96 Y97 F98 G151 G153 K154 T155 E156 F160 N197
BS02 MG A T158 S204 T155 S201
Gene Ontology
Molecular Function
GO:0003774 cytoskeletal motor activity
GO:0005524 ATP binding
GO:0051015 actin filament binding
Cellular Component
GO:0016459 myosin complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:4dbr, PDBe:4dbr, PDBj:4dbr
PDBsum4dbr
PubMed
UniProtQ29122|MYO6_PIG Unconventional myosin-VI (Gene Name=MYO6)

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