Structure of PDB 4dbe Chain A

Receptor sequence
>4dbeA (length=213) Species: 555311 (Saccharolobus solfataricus 98/2) [Search protein sequence]
LKSRVILAMDKPLSYQVLKEMENELYGIKVGLPLVLDLGVDKTRELLIGL
DVEEIIVDFKLADIGYIMKSIVERLSFANSFIAHSFIGVKGSLDELKRYL
DANSKNLYLVAVMSHEGWSTLFADYIKNVIREISPKGIVVGGTKLDHITQ
YRRDFEKMTIVSPGMGSQGGSYGDAVCAGADYEIIGRSIYNAGNPLTALR
TINKIIEDKVMKC
3D structure
PDB4dbe Crystal structure of orotidine 5'-monophosphate decarboxylase from Sulfolobus solfataricus complexed with inhibitor BMP
ChainA
Resolution1.789 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.1.1.23: orotidine-5'-phosphate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BMP A A9 D11 K30 K61 M114 S115 P164 Q169 G187 R188 A8 D10 K29 K60 M113 S114 P163 Q168 G186 R187
BS02 BMP A D64 I65 D63 I64
Gene Ontology
Molecular Function
GO:0004590 orotidine-5'-phosphate decarboxylase activity
GO:0016831 carboxy-lyase activity
Biological Process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0044205 'de novo' UMP biosynthetic process
Cellular Component
GO:0005829 cytosol

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External links
PDB RCSB:4dbe, PDBe:4dbe, PDBj:4dbe
PDBsum4dbe
PubMed
UniProtD0KT28

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