Structure of PDB 4da5 Chain A

Receptor sequence
>4da5A (length=352) Species: 9606 (Homo sapiens) [Search protein sequence]
EQPEPRTRRRAYLWCKEFLPGAWRGLREDEFHISVIRGGLSNMLFQCSLP
DTTATLGDEPRKVLLRLYAEAMVLESVMFAILAERSLGPKLYGIFPQGRL
EQFIPSRRLDTEELSLPDISAEIAEKMATFHGMKMPFNKEPKWLFGTMEK
YLKEVLRIKFTEESRIKKLHKLLSYNLPLELENLRSLLESTPSPVVFCHN
DCQEGNILLLEGRENSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYS
YEKYPFFRANIRKYPTKKQQLHFISSYLPAFQNDFENLSTEEKSIIKEEM
LLEVNRFALASHFLWGLWSIVQAKISSIEFGYMDYAQARFDAYFHQKRKL
GV
3D structure
PDB4da5 Kinetic and mechanistic characterisation of Choline Kinase-alpha.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.32: choline kinase.
2.7.1.82: ethanolamine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0H7 A D306 Q308 Y354 W420 W423 F435 Y437 D201 Q203 Y249 W315 W318 F330 Y332 MOAD: Ki=0.36uM
PDBbind-CN: -logKd/Ki=6.44,Ki=0.36uM
Gene Ontology
Molecular Function
GO:0004103 choline kinase activity
GO:0004104 cholinesterase activity
GO:0004305 ethanolamine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006646 phosphatidylethanolamine biosynthetic process
GO:0006656 phosphatidylcholine biosynthetic process
GO:0006657 CDP-choline pathway
GO:0006869 lipid transport
GO:0008654 phospholipid biosynthetic process
GO:0016310 phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005811 lipid droplet
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:4da5, PDBe:4da5, PDBj:4da5
PDBsum4da5
PubMed23416529
UniProtP35790|CHKA_HUMAN Choline kinase alpha (Gene Name=CHKA)

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