Structure of PDB 4d9t Chain A

Receptor sequence
>4d9tA (length=299) Species: 9606 (Homo sapiens) [Search protein sequence]
SIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEI
EILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSER
EASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGF
AKQLRAENGLLMTPCYTANFVAPEVLERQGYDAACDIWSLGVLLYTMLTG
YTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDP
HQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRN
3D structure
PDB4d9t Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles.
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D539 K541 N544 D561 T581
Catalytic site (residue number reindexed from 1) D125 K127 N130 D147 T167
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0JG A I428 C436 A449 K451 T493 L495 M496 C560 D561 I14 C22 A35 K37 T79 L81 M82 C146 D147
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4d9t, PDBe:4d9t, PDBj:4d9t
PDBsum4d9t
PubMed22466421
UniProtP51812|KS6A3_HUMAN Ribosomal protein S6 kinase alpha-3 (Gene Name=RPS6KA3)

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