Structure of PDB 4d86 Chain A

Receptor sequence
>4d86A (length=374) Species: 9606 (Homo sapiens) [Search protein sequence]
KCFSRTVLAPGVVLIVQQGDLARLPVDVVVNASNEDLKHYGGLAAALSKA
AGPELQADCDQIVKREGRLLPGNATISKAGKLPYHHVIHAVGPRWSGYEA
PRCVYLLRRAVQLSLCLAEKYKYRSIAIPAISSGVFGFPLGRCVETIVSA
IKENFQFKKDGHCLKEIYLVDVSEKTVEAFAEAVKTVFGSLVSPGGLQML
LVKEGVQNAKTDVVVNSVPLDLVLSRGPLSKSLLEKAGPELQEELDTVGQ
GVAVSMGTVLKTSSWNLDCRYVLHVVAPEWRNGSTSSLKIMEDIIRECME
ITESLSLKSIAFPAIGTGNLGFPKNIFAELIISEVFKFSSKNQLKTLQEV
HFLLHPSDHENIQAFSDEFARRAN
3D structure
PDB4d86 Recognition of Mono-ADP-Ribosylated ARTD10 Substrates by ARTD8 Macrodomains.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A A822 G832 L833 S922 S923 G924 V925 F926 D961 V962 A32 G42 L43 S132 S133 G134 V135 F136 D171 V172 MOAD: Kd=6.4uM
BS02 ADP A G1022 V1023 S1034 P1045 L1046 S1049 G1133 T1134 G1135 N1136 L1137 H1172 D1175 G205 V206 S217 P228 L229 S232 G316 T317 G318 N319 L320 H355 D358 MOAD: Kd=6.4uM
External links
PDB RCSB:4d86, PDBe:4d86, PDBj:4d86
PDBsum4d86
PubMed23473667
UniProtQ460N5|PAR14_HUMAN Protein mono-ADP-ribosyltransferase PARP14 (Gene Name=PARP14)

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