Structure of PDB 4d4u Chain A

Receptor sequence
>4d4uA (length=314) Species: 746128 (Aspergillus fumigatus) [Search protein sequence]
STPGAQQVLFRTGIAAVNSTNHLRVYFQDVYGSIRESLYEGSWANGTEKN
VIGNAKLGSPVAATSKELKHIRVYTLTEGNTLQEFAYDSGTGWYNGGLGG
AKFQVAPYSCIAAVFLAGTDALQLRIYAQKPDNTIQEYMWNGDGWKEGTN
LGGALPGTGIGATSFRYTDYNGPSIRIWFQTDDLKLVQRAYDPHKGWYPD
LVTIFDRAPPRTAIAATSFGAGNSSIYMRIYFVNSDNTIWQVCWDHGKGY
HDKGTITPVIQGSEVAIISWGSFANNGPDLRLYFQNGTYISAVSEWVWNR
AHGSQLGRSALPPA
3D structure
PDB4d4u Structural Insights Into Aspergillus Fumigatus Lectin Specificity: Afl Binding Sites are Functionally Non-Equivalent.
ChainA
Resolution1.99 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FUC A R25 E37 Y88 R24 E36 Y87 MOAD: Kd=91.9uM
BS02 FUC A R73 E85 G97 G98 L125 W141 W146 R72 E84 G96 G97 L124 W140 W145 MOAD: Kd=91.9uM
BS03 GAL A Q124 N142 P174 Q123 N141 P173
BS04 FUC A R126 E138 T150 Y192 R125 E137 T149 Y191 MOAD: Kd=91.9uM
BS05 FUC A Y40 R282 E296 Y39 R281 E295 MOAD: Kd=91.9uM
BS06 FUC A R230 Q242 F274 P279 W299 R229 Q241 F273 P278 W298 MOAD: Kd=91.9uM
Gene Ontology
Molecular Function
GO:0030246 carbohydrate binding
GO:0046872 metal ion binding
Biological Process
GO:0008150 biological_process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4d4u, PDBe:4d4u, PDBj:4d4u
PDBsum4d4u
PubMed25760594
UniProtQ4WW81|LECF_ASPFU Fucose-specific lectin (Gene Name=fleA)

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