Structure of PDB 4d2s Chain A

Receptor sequence
>4d2sA (length=249) Species: 9606 (Homo sapiens) [Search protein sequence]
AANECISVKGRIYSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADN
QTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNSW
LKKKIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGMLKLID
FGIATVNYMPPEAIKDMSPKSDVWSLGCILYYMTYGKTPFQQIINQISKL
HAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQI
3D structure
PDB4d2s Discovery and Optimization of a Novel Series of Dyrk1B Kinase Inhibitors to Explore a Mek Resistance Hypothesis.
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D647 K649 N652 D664 T686
Catalytic site (residue number reindexed from 1) D133 K135 N138 D150 T155
Enzyme Commision number 2.7.12.1: dual-specificity kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DYK A I531 V539 K553 G605 N606 I607 D608 S611 L654 I663 I19 V27 K41 G93 N94 I95 D96 S99 L140 I149 MOAD: ic50=0.02uM
PDBbind-CN: -logKd/Ki=7.70,IC50=0.02uM
BindingDB: IC50=20nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4d2s, PDBe:4d2s, PDBj:4d2s
PDBsum4d2s
PubMed25738750
UniProtP33981|TTK_HUMAN Dual specificity protein kinase TTK (Gene Name=TTK)

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