Structure of PDB 4d2b Chain A

Receptor sequence

>4d2bA (length=445) Species: 264199 (Streptococcus thermophilus LMG 18311)

KTFFGQPLGLSTLFMTEMWERFSYYGMRAILLYYMWFLISTGDLHITRAT
AASIMAIYASMVYLSGTIGGFVADRIIGARPAVFWGGVLIMLGHIVLALP
FGASALFGSIILIIIGTGFLKPNVSTLVGTLYDEHDRRRDAGFSIFVFGI
NLGAFIAPLIVGAAQEAAGYHVAFSLAAIGMFIGLLVYYFGGKKTLDPHY
LRPTDPLAPEEVKPLLVKVSLAVAGFIAIIVVMNLVGWNSLPAYINLLTI
VAIAIPVFYFAWMISLRVVSYIPLFIAAVLFWAIEEQGSVVLATFAAERV
DSSWFPVSWFQSLNPLFIMLYTPFFAWLWTANQPSSPTKFAVGLMFAGLS
FLLMAIPGALYGTSGKVSPLWLVGSWALVILGEMLISPVGLSVTTMMSMW
FLSSSVGSALNAQLVTLYNAKSEVAYFSYFGLGSVVLGIVLVFLS

3D structure

• PDB: 4d2b Structural Basis for Polyspecificity in the Pot Family of Proton-Coupled Oligopeptide Transporters.
• Chain: A
• Resolution: 2.35 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	78N	A	I373 A376	I356 A359
BS02	78M	A	I234 M238 A248 I255 F263	I229 M233 A243 I250 F258
BS03	78M	A	V469 F470	V442 F443
BS04	78M	A	S180 F187	S175 F182
BS05	78N	A	R85 P86 F89 Y193	R80 P81 F84 Y188
BS06	78M	A	V384 S385 W388	V367 S368 W371
BS07	78N	A	L212 L221	L207 L216
BS08	78N	A	L369 I373 V451	L352 I356 V424

Gene Ontology

Molecular Function

• GO:0022857 transmembrane transporter activity
• GO:0042802 identical protein binding
• GO:1904680 peptide transmembrane transporter activity

Biological Process

• GO:0006857 oligopeptide transport
• GO:0015833 peptide transport
• GO:0055085 transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:4d2b, PDBe:4d2b, PDBj:4d2b
• PDBsum: 4d2b
• PubMed: 24916388
• UniProt: Q5M4H8