Structure of PDB 4cyg Chain A

Receptor sequence
>4cygA (length=463) Species: 9606 (Homo sapiens) [Search protein sequence]
KQDTFIAAVYEHAAILPNATLTPVSREEALALMNRNLDILEGAITSAADQ
GAHIIVTPEDAIYGWNFNRDSLYPYLEDIPDPEVNWIPCNNRNRFGQTPV
QERLSCLAKNNSIYVVANIGDKKPCDTSDPQCPPDGRYQYNTDVVFDSQG
KLVARYHKQNLFMGENQFNVPKEPEIVTFNTTFGSFGIFTCFDILFHDPA
VTLVKDFHVDTIVFPTAWMNVLPHLSAVEFHSAWAMGMRVNFLASNIHYP
SKKMTGSGIYAPNSSRAFHYDMKTEEGKLLLSQLDSHPSHSAVVNWTSYA
SSIEALSSGNKEFKGTVFFDEFTFVKLTGVAGNYTVCQKDLCCHLSYKMS
ENIPNEVYALGAFDGLHTVEGRYYLQICTLLKCKTTNLNTCGDSAETAST
RFEMFSLSGTFGTQYVFPEVLLSENQLAPGEFQVSTDGRLFSLKPTSGPV
LTVTLFGRLYEKD
3D structure
PDB4cyg The Structure of Vanin-1: A Key Enzyme Linking Metabolic Disease and Inflammation
ChainA
Resolution2.3 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.5.1.92: pantetheine hydrolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RRV A E79 F182 E185 C211 F212 A237 W238 M239 F338 E59 F162 E165 C191 F192 A217 W218 M219 F318
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0017159 pantetheine hydrolase activity
Biological Process
GO:0002526 acute inflammatory response
GO:0002544 chronic inflammatory response
GO:0006954 inflammatory response
GO:0006979 response to oxidative stress
GO:0015938 coenzyme A catabolic process
GO:0015939 pantothenate metabolic process
GO:0033089 positive regulation of T cell differentiation in thymus
GO:0045087 innate immune response
GO:0098609 cell-cell adhesion
GO:1902177 positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0035577 azurophil granule membrane
GO:0098552 side of membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4cyg, PDBe:4cyg, PDBj:4cyg
PDBsum4cyg
PubMed25478849
UniProtO95497|VNN1_HUMAN Pantetheinase (Gene Name=VNN1)

[Back to BioLiP]