Structure of PDB 4cvu Chain A

Receptor sequence
>4cvuA (length=913) Species: 5544 (Trichoderma harzianum) [Search protein sequence]
GKASIHDLALQKWTVTNEYGNITVPGKFPSQAHLDLHAAGVIGESNNGLN
DFDLRWIAAQNWTYTSKPISGLSKHSDIATWLVFDGLDTYATVKFCDHIV
GTPDNQFRQWFYDVSSALASCKSDPVLSINFGSVPRIINAINASDEVQHW
PASVVYPFEYPNRQWVRKEQNDFGWDWGPAFSPVGPWQPGRIVQLSKGGE
LYSLNTDIDIFRKGQFNNFAPDQTAPWVVNASLDFLGTLPKHASMSVIIT
DASVLYSGKLEGVTQSDMTVTGSVTIDAHKPKLWWPRDMGNQQLYNITVS
VSSAGSKTPILVSQRRVGFRTILFSSGNITDAQIASGITPGNNWHFEING
HEFYAKGANLIPPDAFWPRVTSDRMNRLFDSVESQNFNMLRVWSSGTYLP
DWIYDIADERGVLLWSEFQFSDTLYPDSDDFKANVVGEITYNVRRLNHHA
SLACWMGGNEFENLMLPIAQGADPATYPYVLGQYENLFITTLFNVLAANS
HSISYSPCSANNGWLEIDLDLPVPIVERYYNTTSGHIYGDTDFYNYDTSV
SFDTSAYPVGRFANEFGFISMPSIQTWQQAVDPEELSFNSTTVILRNHHY
PAGGLTRNIHNSTLGQVEMTLAVERYYPTPDKTDPVANFSSWCHATQLFQ
ADMYKSEIQFYRRGSGLPERQLGSLYWQLNDIWQAPTWAGLEYDGRWKVL
PYVSRRTYEHVIASAFWNYTANELEIWVTSDLWEPVAGEVSLTWVDLKGK
PIANNAGMTKSTKFNVGAINTTQIITANIQSDLKIPDTSDAVLVIELTAH
GKLPNAASSKTTTFTHHNHFLPVWPNQAKVSDPKLHLSYNKSTKKFTVEA
TAGVSLYTWLTHPAGVLGFFDDNAFVLRPGEKKEVGFTLQQDTTGGKWTE
QVTVESLWDLTTP
3D structure
PDB4cvu Insights into the structure and function of fungal beta-mannosidases from glycoside hydrolase family 2 based on multiple crystal structures of the Trichoderma harzianum enzyme.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.25: beta-mannosidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MAN A H123 I124 H98 I99
BS02 MAN A G511 E514 N515 G482 E485 N486
BS03 MAN A Y508 G511 Q512 N515 Y479 G482 Q483 N486
BS04 MAN A N523 L548 N494 L519
BS05 MAN A Q294 S295 Q265 S266
BS06 MAN A D259 M297 T298 R473 D234 M268 T269 R444
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
Biological Process
GO:0005975 carbohydrate metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4cvu, PDBe:4cvu, PDBj:4cvu
PDBsum4cvu
PubMed24975648
UniProtA0A075B5H6

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