Structure of PDB 4cu8 Chain A

Receptor sequence
>4cu8A (length=848) Species: 170187 (Streptococcus pneumoniae TIGR4) [Search protein sequence]
AVTNEEVNQMIEDRKVDFNQNWYFKLNANSKEAIKPDADVSTWKKLDLPY
DWSIFNDFDHESPAQNEGGQLNGGEAWYRKTFKLDEKDLKKNVRLTFDGV
YMDSQVYVNGQLVGHYPNGYNQFSYDITKYLQKDGRENVIAVHAVNKQPS
SRWYSGSGIYRDVTLQVTDKVHVEKNGTTILTPKLEEQQHGKVETHVTSK
IVNTDDKDHELVAEYQIVERGGHAVTGLVRTASRTLKAHESTSLDAILEV
ERPKLWTVLNDKPALYELITRVYRDGQLVDAKKDLFGYRYYHWTPNEGFS
LNGERIKFHGVSLHHDHGALGAEENYKAEYRRLKQMKEMGVNSIRTTHNP
ASEQTLQIAAELGLLVQEEAFDTWYGGKKPYDYGRFFEKDATHPEARKGE
KWSDFDLRTMVERGKNNPAIFMWSIGNEIGEANGDAHSLATVKRLVKVIK
DVDKTRYVTMGADKFRFGNGSGGHEKIADELDAVGFNYSEDNYKALRAKH
PKWLIYGSETSSATRTRGSYYRPERELKHSNGPERNYEQSDYGNDRVGWG
KTATASWTFDRDNAGYAGQFIWTGTDYIGEPTPWHNQNQTPVKSSYFGIV
DTAGIPKHDFYLYQSQWVSVKKKPMVHLLPHWNWENKELASKVADSEGKI
PVRAYSNASSVELFLNGKSLGLKTFNKKQTSDGRTYQEGANANELYLEWK
VAYQPGTLEAIARDESGKEIARDKITTAGKPAAVRLIKEDHAIAADGKDL
TYIYYEIVDSQGNVVPTANNLVRFQLHGQGQLVGVDNGEQASRERYKAQA
DGSWIRKAFNGKGVAIVKSTEQAGKFTLTAHSDLLKSNQVTVFTGKKE
3D structure
PDB4cu8 Unravelling the Multiple Functions of the Architecturally Intricate Streptococcus Pneumoniae Beta-Galactosidase, Bgaa.
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R288 H450 H484 T509 Y511 E564 Y629 E645 S730 F733
Catalytic site (residue number reindexed from 1) R152 H314 H348 T373 Y375 E428 Y493 E509 S594 F597
Enzyme Commision number 3.2.1.23: beta-galactosidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DGJ A R288 H484 N563 E564 E645 S648 W685 W708 E716 F733 R152 H348 N427 E428 E509 S512 W549 W572 E580 F597 MOAD: Ki=33.9uM
PDBbind-CN: -logKd/Ki=4.47,Ki=33.9uM
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
Biological Process
GO:0005975 carbohydrate metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4cu8, PDBe:4cu8, PDBj:4cu8
PDBsum4cu8
PubMed25210925
UniProtA0A0H2UP19

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