Structure of PDB 4ct1 Chain A

Receptor sequence
>4ct1A (length=284) Species: 9606 (Homo sapiens) [Search protein sequence]
KKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKIVEKRHVHKENKIP
YVQREKDVMSRLDHPFFVKLYFCFQDDEKLYLGLSYAKNGELLKYIRKIG
SFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFG
TAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQL
VAGLPPFRAGNEGLIFAKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRL
GCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLT
3D structure
PDB4ct1 Molecular Mechanism of Regulation of the Atypical Protein Kinase C by N-Terminal Domains and an Allosteric Small Compound.
ChainA
Resolution1.85 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D205 K207 E209 N210 D223 T245
Catalytic site (residue number reindexed from 1) D130 K132 E134 N135 D148 T170
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A G89 G91 S92 S94 V96 A109 A162 E166 L212 G14 G16 S17 S19 V21 A34 A87 E91 L137
BS02 31S A V127 E130 K131 C148 F149 L155 L157 V52 E55 K56 C73 F74 L80 L82
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4ct1, PDBe:4ct1, PDBj:4ct1
PDBsum4ct1
PubMed24836908
UniProtO15530|PDPK1_HUMAN 3-phosphoinositide-dependent protein kinase 1 (Gene Name=PDPK1)

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