Structure of PDB 4csj Chain A

Receptor sequence
>4csjA (length=247) Species: 9606 (Homo sapiens) [Search protein sequence]
PTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQMIAAVKWAK
AIPGFRNLHLDDQMTLLQYSWMSLMAFALGWRSYRQSSANLLCFAPDLII
NEQRMTLPDMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDG
LKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVV
ENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQ
3D structure
PDB4csj The Discovery of Potent and Selective Non-Steroidal Glucocorticoid Receptor Modulators, Suitable for Inhalation.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V575 K579 R585 L589 M593 Q597 E751 M752 E755 N759 V46 K50 R56 L60 M64 Q68 E222 M223 E226 N230
BS02 NN7 A M560 L563 N564 L566 G567 Q570 M604 A607 L608 R611 F623 Q642 C736 M31 L34 N35 L37 G38 Q41 M75 A78 L79 R82 F94 Q113 C207 MOAD: ic50=4.9nM
PDBbind-CN: -logKd/Ki=8.31,IC50=4.9nM
BindingDB: IC50=1.5nM
External links
PDB RCSB:4csj, PDBe:4csj, PDBj:4csj
PDBsum4csj
PubMed24755427
UniProtP04150|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

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