Structure of PDB 4crl Chain A

Receptor sequence
>4crlA (length=339) Species: 9606 (Homo sapiens) [Search protein sequence]
DDKMDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDK
DYALKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLF
DYAEHDLWHIIKFHRASVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLK
PANILVMGEGPERGRVKIADMGFARLFNSPLVTFWYRAPELLLGARHYTK
AIDIWAIGCIFAELLTSEPIFHCRQPYHHDQLDRIFNVMGFPADKDWEDI
KKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDP
IKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFL
3D structure
PDB4crl Mediator Kinase Inhibition Further Activates Super-Enhancer- Associated Genes in Aml
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D151 K153 N156 D173 N181 T196
Catalytic site (residue number reindexed from 1) D148 K150 N153 D170 N178 T183
Enzyme Commision number 2.7.11.22: cyclin-dependent kinase.
2.7.11.23: [RNA-polymerase]-subunit kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C1I A V27 Y32 V35 A50 I79 A100 W105 H106 A155 L158 V30 Y35 V38 A53 I82 A103 W108 H109 A152 L155 MOAD: Kd=195pM
PDBbind-CN: -logKd/Ki=9.71,Kd=195pM
BindingDB: Kd=17nM,IC50=12nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4crl, PDBe:4crl, PDBj:4crl
PDBsum4crl
PubMed26416749
UniProtP49336|CDK8_HUMAN Cyclin-dependent kinase 8 (Gene Name=CDK8)

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