Structure of PDB 4cqo Chain A

Receptor sequence
>4cqoA (length=510) Species: 9606 (Homo sapiens) [Search protein sequence]
YDDPPGLREKAEYLLREWVNLYHSAAAGRDSTKAFSAFVGQMHQQGILKT
DDLITRFFRLCTEMCVEISYRAQAEPTMIRAKCYHNLDAFVRLIALLVKH
SGEATNTVTKINLLNKVLGIVVGVLLQDHDVRQSEFQQLPYHRIFIMLLL
ELNAPEHVLETINFQTLTAFCNTFHILRPTKAPGFVYAWLELISHRIFIA
RMLAHTPQQKGWPMYAQLLIDLFKYLAPFLRNVTKPMQILYKGTLRVLLV
LLHDFPEFLCDYHYGFCDVIPPNCIQLRNLILSAFPRNMRLPDPFTPNLK
VDMLSEINIAPRILTNFTGVMPPQFKKDLDSYLKTRSPVTFLSDLRSNLQ
VSNEPGNRYNLQLINALVLYVGTQAIAHIHNKGSTPSMSTITHSAHMDIF
QNLAVDLDTEGRYLFLNAIANQLRYPNSHTHYFSCTMLYLFAEANTEAIQ
EQITRVLLERLIVNRPHPWGLLITFIELIKNPAFKFWNHEFVHCAPEIEK
LFQSVAQCCM
3D structure
PDB4cqo Structural Basis for the Nanos-Mediated Recruitment of the Ccr4-not Complex and Translational Repression
ChainA
Resolution2.8 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K2331 W2338 F2353 Q2354 A2357 M2361 K480 W487 F502 Q503 A506 M510
BS02 peptide A R1992 L1999 E2040 H2044 R143 L150 E191 H195
Gene Ontology
Biological Process
GO:0017148 negative regulation of translation
Cellular Component
GO:0030015 CCR4-NOT core complex

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4cqo, PDBe:4cqo, PDBj:4cqo
PDBsum4cqo
PubMed24736845
UniProtA5YKK6|CNOT1_HUMAN CCR4-NOT transcription complex subunit 1 (Gene Name=CNOT1)

[Back to BioLiP]