Structure of PDB 4cno Chain A

Receptor sequence
>4cnoA (length=247) Species: 90370 (Salmonella enterica subsp. enterica serovar Typhi) [Search protein sequence]
KTVTVKNLIIGEGMPKIIVSLMGRDINSVKAEALAYREATFDILEWRVDH
FMDIASTQSVLTAARVIRDAMPDIPLLFTFRSAKEGGEQTITTQHYLTLN
RAAIDSGLVDMIDLELFTGDADVKATVDYAHAHNVYVVMSNHDFHQTPSA
EEMVLRLRKMQALGADIPKIAVMPQSKHDVLTLLTATLEMQQHYADRPVI
TMSMAKEGVISRLAGEVFGSAATFGAVKPGQIAVNDLRSVLMILHNA
3D structure
PDB4cno Insights into substrate binding and catalysis in bacterial type I dehydroquinase.
ChainA
Resolution1.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E86 H143 K170
Catalytic site (residue number reindexed from 1) E85 H142 K169
Enzyme Commision number 4.2.1.10: 3-dehydroquinate dehydratase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9PY A S21 E46 R48 R213 F225 Q236 S20 E45 R47 R212 F224 Q231
Gene Ontology
Molecular Function
GO:0003855 3-dehydroquinate dehydratase activity
GO:0016829 lyase activity
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009073 aromatic amino acid family biosynthetic process
GO:0009423 chorismate biosynthetic process
GO:0046279 3,4-dihydroxybenzoate biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4cno, PDBe:4cno, PDBj:4cno
PDBsum4cno
PubMed24957267
UniProtP24670|AROD_SALTI 3-dehydroquinate dehydratase (Gene Name=aroD)

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