Structure of PDB 4cn5 Chain A

Receptor sequence
>4cn5A (length=81) Species: 9606 (Homo sapiens) [Search protein sequence]
MFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCL
IDKRQRNRCQYCRYQKCLAMGMKREAVQEER
3D structure
PDB4cn5 Structural Basis of Natural Promoter Recognition by the Retinoid X Nuclear Receptor.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A K145 H146 Y147 R164 Q206 E208 R209 K17 H18 Y19 R36 Q78 E80 R81 PDBbind-CN: Kd=40nM
BS02 dna A E153 G154 R161 R184 N185 Q188 R191 E25 G26 R33 R56 N57 Q60 R63 PDBbind-CN: Kd=40nM
BS03 ZN A C135 C138 C155 C7 C10 C27
BS04 ZN A C171 C177 C187 C190 C43 C49 C59 C62
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:4cn5, PDBe:4cn5, PDBj:4cn5
PDBsum4cn5
PubMed25645674
UniProtP19793|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)

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