Structure of PDB 4clz Chain A

Receptor sequence
>4clzA (length=458) Species: 9606 (Homo sapiens) [Search protein sequence]
MNTPKEEFQDWPIVRIAAHLPDLIVYGHFSPERPFMDYFDGVLMFVDISG
FTAMTEKFSSAMYMDRGAEQLVEILNYHISAIVEKVLIFGGDILKFAGDA
LLALWRVERKQLKNIITVVIKCSLEIHGLFETVKIGLAAGHISMLVFGDE
THSHFLVIGQAVDDVRLAQNMAQMNDVILSPNCWQLCDRSMIEIESVPDQ
RAVKVNFLKPPPNFNFDEFFTKCTTFMHYYPSGEHKNLLRLACTLKPDPE
LEMSLQKYVMESILKQIDNKQLQGYLSELRPVTIVFVNLMFEDQDKAEEI
GPAIQDAYMHITSVLKIFQGQINKVFMFDKGCSFLCVFGFPGEKVPDELT
HALECAMDIFDFCSQVHKIQTVSIGVASGIVFCGIVGHTVRHEYTVIGQK
VNLAARMMMYYPGIVTCDSVTYNGSNLPAYFFKELPKKVMKGVADSGPLY
QYWGRTEK
3D structure
PDB4clz Crystal Structures of Human Soluble Adenylyl Cyclase Reveal Mechanisms of Catalysis and of its Activation Through Bicarbonate.
ChainA
Resolution1.9 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 4.6.1.1: adenylate cyclase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4DS A F8 D10 V14 R15 A252 C253 Q276 I277 N279 Q283 T399 F8 D10 V14 R15 A242 C243 Q266 I267 N269 Q273 T389 PDBbind-CN: -logKd/Ki=4.37,IC50=43uM
BS02 4DS A F45 K95 A97 L101 L102 R176 F336 F338 D339 R416 M419 Y420 F45 K95 A97 L101 L102 R166 F326 F328 D329 R406 M409 Y410 PDBbind-CN: -logKd/Ki=4.37,IC50=43uM
BS03 4DS A F51 M54 K57 F58 M62 Y63 H78 F51 M54 K57 F58 M62 Y63 H78 PDBbind-CN: -logKd/Ki=4.37,IC50=43uM
Gene Ontology
Biological Process
GO:0009190 cyclic nucleotide biosynthetic process
GO:0035556 intracellular signal transduction

View graph for
Biological Process
External links
PDB RCSB:4clz, PDBe:4clz, PDBj:4clz
PDBsum4clz
PubMed24567411
UniProtQ96PN6|ADCYA_HUMAN Adenylate cyclase type 10 (Gene Name=ADCY10)

[Back to BioLiP]