Structure of PDB 4clh Chain A

Receptor sequence
>4clhA (length=252) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence]
EAPAAVVTGAAKRIGRAIAVKLHQTGYRVVIHYHNSAEAAVSLADELNKE
RSNTAVVCQADLTNSNVLPASCEEIINSCFRAFGRCDVLVNNASAFYPTP
LVQGKTVETQVAELIGTNAIAPFLLTMSFAQRQKSSNLSIVNLCDAMVDQ
PCMAFSLYNMGKHALVGLTQSAALELAPYGIRVNGVAPGVSLLPVAMGEE
EKDKWRRKVPLGRREASAEQIADAVIFLVSGSAQYITGSIIKVDGGLSLV
HA
3D structure
PDB4clh Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1.
ChainA
Resolution1.85 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) R14 D161 Y174 K178
Catalytic site (residue number reindexed from 1) R13 D145 Y158 K162
Enzyme Commision number 1.5.1.33: pteridine reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP A R14 I15 H33 Y34 H35 N36 S37 D62 L63 N93 A94 S95 T126 L159 K178 P204 G205 S207 R13 I14 H32 Y33 H34 N35 S36 D61 L62 N92 A93 S94 T117 L143 K162 P188 G189 S191
BS02 W8G A S95 F97 Y174 P210 S94 F96 Y158 P194 MOAD: Ki=8.6uM
BS03 W8G A F97 D161 C168 F171 W221 F96 D145 C152 F155 W205 MOAD: Ki=8.6uM
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016491 oxidoreductase activity
GO:0047040 pteridine reductase activity

View graph for
Molecular Function
External links
PDB RCSB:4clh, PDBe:4clh, PDBj:4clh
PDBsum4clh
PubMed25007262
UniProtO76290

[Back to BioLiP]