Structure of PDB 4clb Chain A

Receptor sequence
>4clbA (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB4clb The Structure Based Design of Dual Hdac/Bet Inhibitors as Novel Epigenetic Probes.
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 83T A W81 L92 N140 I146 W40 L51 N99 I105 PDBbind-CN: -logKd/Ki=6.55,IC50=0.28uM
External links
PDB RCSB:4clb, PDBe:4clb, PDBj:4clb
PDBsum4clb
PubMed
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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