Structure of PDB 4cl9 Chain A

Receptor sequence
>4cl9A (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB4cl9 The Structure Based Design of Dual Hdac/Bet Inhibitors as Novel Epigenetic Probes.
ChainA
Resolution1.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IES A W81 P82 Q84 Q85 K91 L92 N140 I146 M149 W40 P41 Q43 Q44 K50 L51 N99 I105 M108 PDBbind-CN: -logKd/Ki=7.30,IC50=0.05uM
External links
PDB RCSB:4cl9, PDBe:4cl9, PDBj:4cl9
PDBsum4cl9
PubMed
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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