Structure of PDB 4ckr Chain A

Receptor sequence
>4ckrA (length=295) Species: 9606 (Homo sapiens) [Search protein sequence]
MPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHP
LLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCM
ITDYMENGDLNQFLSAHQLEDPTISYPMLLHVAAQIASGMRYLATLNFVH
RDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVVLPIRWMAWECILMG
KFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQV
YLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFLAEDALNTV
3D structure
PDB4ckr Discovery of a Potent and Selective Ddr1 Receptor Tyrosine Kinase Inhibitor.
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D766 R770 N771 D784 A793
Catalytic site (residue number reindexed from 1) D152 R156 N157 D170 A179
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DI1 A A653 K655 E672 M676 T701 Y703 M704 V763 H764 R765 L773 I782 A783 D784 F785 A54 K56 E73 M77 T102 Y104 M105 V149 H150 R151 L159 I168 A169 D170 F171 MOAD: ic50=105nM
PDBbind-CN: -logKd/Ki=6.98,IC50=105nM
BindingDB: IC50=105nM,EC50=86nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4ckr, PDBe:4ckr, PDBj:4ckr
PDBsum4ckr
PubMed23899692
UniProtQ08345|DDR1_HUMAN Epithelial discoidin domain-containing receptor 1 (Gene Name=DDR1)

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