Structure of PDB 4cik Chain A

Receptor sequence
>4cikA (length=81) Species: 9606 (Homo sapiens) [Search protein sequence]
SECKTGNGKNYRGTMSKTKNGITCQKWSSTSPHRPRFSPATHPSEGLEEN
YCRNPDNDPQGPWCYTTDPEKRYDYCDILEC
3D structure
PDB4cik Discovery of the Fibrinolysis Inhibitor Azd6564, Acting Via Interference of a Protein-Protein Interaction.
ChainA
Resolution1.78 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.7: plasmin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XO3 A R35 D55 D57 W62 Y64 R71 Y72 R36 D56 D58 W63 Y65 R72 Y73 PDBbind-CN: -logKd/Ki=6.43,IC50=0.37uM
BindingDB: IC50=950nM
External links
PDB RCSB:4cik, PDBe:4cik, PDBj:4cik
PDBsum4cik
PubMed24900876
UniProtP00747|PLMN_HUMAN Plasminogen (Gene Name=PLG)

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